The interdisciplinary Brain Science Center in the Penn Mahoney Institute for Neurosciences provides infrastructure support for research on human cognition, perception, affect, disordered cognition, and extension to preclinical models. By consolidating state-of-the-art methodological expertise in these domain areas as services, the Brain Science Center seeks to facilitate cutting-edge research using a largely shared set of methods and tools for elucidating brain-behavior relationships in health and disease.